tryparsamide वाक्य
उदाहरण वाक्य
मोबाइल
- In 1925, he encouraged use of tryparsamide to cure sleeping sickness.
- Drug advances for sleeping sickness included Germanin and tryparsamide.
- They also investigated the used of tryparsamide as a possible treatment for syphilis.
- Tryparsamide was a standard treatment for syphilis until penicillin replaced it in 1950.
- Variants of tryparsamide, as Flexner named it, continue to be administered today.
- Nonetheless, tryparsamide became the drug of choice for chemotherapy of sleeping sickness for several decades.
- American medical missionary Arthur Lewis Piper was active in using tryparsamide to treat sleeping sickness in the Belgian Congo in 1925.
- Tryparsamide was announced in the " Journal of Experimental Medicine " in 1919 and tested in the Belgian Congo by Louise Pearce of the Rockefeller Institute in 1920.
- Human trials also revealed that a side effect of other arsenical compounds, damage to the optic nerve and loss of vision, could occur with high or repeated doses of tryparsamide.
- There she worked with a local hospital and laboratory to design and carry out a drug testing protocol for human trials to establish tryparsamide's safety, effectiveness, and optimum dosage.
- By 1922, Suramin was generally combined with tryparsamide ( another pentavalent organoarsenic drug ), the first drug to enter the nervous system and be useful in the treatment of the second stage of the gambiense form.
- The trio of physicians at Wisconsin went on to publish more than 100 papers on neurosyphilis; in particular, they developed and refined an alternative to Wagner-Jauregg therapy, using an arsenical medication called tryparsamide.
- The Rockefeller Institute sent Louise Pearce to L & eacute; opoldville in the Belgian Congo in 1920 to test tryparsamide, " trusting her vigorous personality to carry out an assignment none too easy for a woman physician and not without its dangers ".
- Although it was generally much less powerful against spirochetes than against trypanosomes, tryparsamide's ability to pass the blood-brain barrier and enter the central nervous system made it a useful treatment for syphilis of the brain and spinal cord and the chronic form, general paresis.
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