| 1. | Xanthines such as caffeine and theobromine are cAMP-phosphodiesterase inhibitors.
|
| 2. | It is caused by a deficiency of the enzyme xanthine oxidase.
|
| 3. | Caffeine, like other xanthines, also acts as a phosphodiesterase inhibitor.
|
| 4. | This pathway also is independent of the enzyme activity of xanthine oxidase.
|
| 5. | By inhibiting xanthine oxidase, it reduces uric acid production.
|
| 6. | Hypoxanthine is produced from adenine, xanthine from guanine.
|
| 7. | The xanthine core of caffeine contains two fused rings, a pyrimidinedione and imidazole.
|
| 8. | First, guanine gets deaminated to become xanthine.
|
| 9. | Synthesis of theobromine from xanthine was first reported in 1882 by Hermann Emil Fischer.
|
| 10. | In the liver, theobromine is metabolized into xanthine and subsequently into methyluric acid.
|
मोबाइल