gelatinase वाक्य
उदाहरण वाक्य
मोबाइल
- Gelatinase B may play an important role in angiogenesis and neovascularization.
- This enzyme is similar to gelatinase A, but possesses a further domain.
- Caseinolytic and gelatinase activities are normally present.
- Slough, southeast England-based Celltech has patented a number of inhibitors of human gelatinase.
- Effects of Enterococcus faecalis fsr genes on production of gelatinase and a serine protease and virulence.
- For example, gelatinase B appears to be involved in the remodeling associated with malignant glioma neovascularization.
- When interacting with TGF-?, Gelatinase B also stimulates collagen contraction, aiding in wound closure.
- Gelatinase B has been found to be associated with numerous pathological processes, including immunologic and vascular diseases.
- Elevated gelatinase B levels can also be found in the cases of rheumatoid arthritis and focal brain ischemia.
- The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family.
- Knock-out models of Gelatinase B result in delayed apoptosis, vascularization, and ossification of hypertrophic chondrocytes.
- It is expressed by osteoclasts, and is known to be required for osteoclast migration and is a powerful gelatinase.
- Gelatinase B, along with elastase, appears to be a regulatory factor in neutrophil migration across the basement membrane.
- In in vitro experiments, it has been demonstrated that gelatinase B is greatly upregulated during human respiratory epithelial healing.
- Gelatinase B plays a central role in tumor progression, from angiogenesis, to stromal remodeling, and ultimately metastasis.
- However, because of its physiologic function, it may be difficult to leverage Gelatinase B inhibition into cancer therapy modalities.
- In a mouse model, Gelatinase B deficiency resulted in resistance to endotoxin shock, suggesting that Gelatinase B is important in sepsis.
- In a mouse model, Gelatinase B deficiency resulted in resistance to endotoxin shock, suggesting that Gelatinase B is important in sepsis.
- Lastly, there is significant evidence that Gelatinase B is required for the recruitment of endothelial stem cells, a critical component of angiogenesis
- The treatment has inhibited the ability of cancerous tumors to grow and spread in animal tests by inhibiting gelatinase enzymes that help tumors spread, Celltech said.
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