glutaminase वाक्य
उदाहरण वाक्य
मोबाइल
- In eukaryotes, this enzyme contains a glutaminase domain related to nitrilase.
- ADP is the strongest adenine nucleotide activator of glutaminase.
- Glutaminase has an important role in glial cells.
- Glutaminase has tissue-specific isoenzymes.
- Administration of antioxidants or glutaminase inhibitor can reduce this mitochondrial transition, and potentially also astrocyte remodeling.
- One of the most important roles of glutaminase is found in the axonal terminals of neurons in the central nervous system.
- The last clinical results were published in 2008, though not as DON monotherapy but in combination with a recombinant glutaminase.
- Glutaminase is also expressed in the epithelial cells of the renal tubules, where the produced ammonia is excreted as ammonium ions.
- The structure of Glutaminase has been determined using X-ray diffraction to a resolution of up to 1.73 ?
- Glutamate is synthesized in the central nervous system from glutamine as part of the glutamate-glutamine cycle by the enzyme glutaminase.
- During chronic acidosis, glutaminase is induced in the kidney, which leads to an increase in the amount of ammonium ions excreted.
- The first part of the mechanism occurs in the active site of the glutaminase domain and releases an ammonia group from glutamine by hydrolysis.
- Glutaminase is expressed and active in periportal hepatocytes, where it generates NH 3 ( ammonia ) for urea synthesis, as does glutamate dehydrogenase.
- DON is not approved as pharmaceutical agent, but is tested in combination with a recombinant glutaminase in clinical trials for the treatment of different solid tumors.
- Cortisol's only direct effect on the hydrogen-ion excretion of the kidneys is to stimulate the excretion of ammonium ions by deactivating the renal glutaminase enzyme.
- The enzyme consists of two domains : a glutaminase domain that produces ammonia from glutamine by hydrolysis and a phosphoribosyltransferase domain that binds the ammonia to ribose-5-phosphate.
- There is biochemical evidence that shows rises in ammonia can inhibit glutaminase and therefore limit the rate of synthesis of neurotransmitters such as glutamate, which can explain the developmental delay in argininosuccinic aciduria patients.
- Glutaminase can also be found in the intestines, whereby hepatic portal ammonia can reach as high as 0.26 mM ( compared to an arterial blood ammonia of 0.02 mM ).
- Phosphate-activated mitochondrial glutaminase ( GLS1 ) is suggested to be linked with elevated metabolism, decreased intracellular reactive oxygen species ( ROS ) levels, and overall decreased DNA oxidation in both normal and stressed cells.
- The glutaminase domain is homologous to other N-terminal nucleophile ( Ntn ) hydrolases The free N terminus acts as a base to activate the nucleophile and protonate the leaving group in the hydrolytic reaction, in this case ammonia.
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