| 1. | In eukaryotes, this enzyme contains a glutaminase domain related to nitrilase.
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| 2. | ADP is the strongest adenine nucleotide activator of glutaminase.
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| 3. | Glutaminase has an important role in glial cells.
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| 4. | Glutaminase has tissue-specific isoenzymes.
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| 5. | Administration of antioxidants or glutaminase inhibitor can reduce this mitochondrial transition, and potentially also astrocyte remodeling.
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| 6. | One of the most important roles of glutaminase is found in the axonal terminals of neurons in the central nervous system.
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| 7. | The last clinical results were published in 2008, though not as DON monotherapy but in combination with a recombinant glutaminase.
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| 8. | Glutaminase is also expressed in the epithelial cells of the renal tubules, where the produced ammonia is excreted as ammonium ions.
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| 9. | The structure of Glutaminase has been determined using X-ray diffraction to a resolution of up to 1.73 ?
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| 10. | Glutamate is synthesized in the central nervous system from glutamine as part of the glutamate-glutamine cycle by the enzyme glutaminase.
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