Thus, mutations in " IDH1 " and " IDH2 " generate a DNA CpG island methylator phenotype or CIMP that causes promoter hypermethylation and concomitant silencing of tumor suppressor genes such as DNA repair genes " MGMT " and " ERCC1 ".
2.
The DNA methylation data analysis team, led by Houtan Noushmehr, PhD and Peter Laird, PhD, identified a distinct subset of glioma samples which displays concerted hypermethylation at a large number of loci, indicating the existence of a glioma-CpG island methylator phenotype ( G-CIMP ).
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