| 1. | Meticillin is actually a penicillinase-resistant B-lactam antibiotic.
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| 2. | Penicillinase production is one mechanism by which bacteria can become penicillin resistant.
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| 3. | TEM-1 is a penicillinase specific for penicillins.
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| 4. | Methicillin is a derivative of penicillin that was created to resist the penicillinase enzyme.
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| 5. | More than 50 % of the isolates taken from infected patients contain the penicillinase enzyme.
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| 6. | The spread of the penicillinase resistance was much faster compared to the chromosomal-mediated resistance mechanisms.
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| 7. | With his colleagues, he also discovered penicillinase, a penicillin-destroying enzyme that disclosed much about resistance to penicillin.
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| 8. | Penicillinase-resistant beta-lactams such as methicillin were developed, but there is now widespread resistance to even these.
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| 9. | Meticillin is insensitive to beta-lactamase ( also known as penicillinase ) enzymes secreted by many penicillin-resistant bacteria.
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| 10. | Meticillin is not bound and hydrolysed by penicillinase, meaning it can kill the bacteria, even if this enzyme is present.
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