topoisomerase वाक्य
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- Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II ( compares with the better known agent etoposide ).
- Use of topoisomerase inhibitors for antineoplastic treatments may lead to secondary neoplasms because of DNA damaging properties of the compounds.
- This regulatory role may be directly associated with the role of topoisomerase II in disjoining sister chromatids prior to anaphase.
- Inhibition of Aurora B due to loss of topoisomerase II seems to depend on BubR1 activity ( see below ).
- This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription.
- Structure of yeast topoisomerase II bound to a doubly nicked 34-mer duplex DNA ( PDB ID = 2RGR ).
- In topoisomerase II-depleted cells, Aurora B and INCENP do not transfer to the central spindle in late mitosis.
- Amrubicin acts by inhibiting topoisomerase II, and has been compared in clinical trials with topotecan, a Topoisomerase I inhibitor.
- Amrubicin acts by inhibiting topoisomerase II, and has been compared in clinical trials with topotecan, a Topoisomerase I inhibitor.
- It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.
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