topoisomerase वाक्य
उदाहरण वाक्य
मोबाइल
- Topoisomerase IIA plays an essential role in resolving these topological problems.
- Topoisomerase I and SR proteins also interact to increase genome stabilization.
- They act as anti-cancer drugs by inhibiting topoisomerase II.
- Some organisms have two isoforms of topoisomerase II : alpha and beta.
- Topoisomerase poisons have been extensively used as both anticancer and antibacterial therapies.
- Cadmium cations react with the topoisomerase in the following manner:
- The topo I of both prokaryotes and eukaryotes are the type I topoisomerase.
- CcdB protein is a topoisomerase poison from " Escherichia coli ".
- Topoisomerase inhibitors can also function as antibacterial agents.
- Also, cells deficient in topoisomerase II show significantly reduced Aurora B kinase activity.
- The introduction of DSBs in DNA often employs the topoisomerase-like protein SPO11.
- It is believed that eukaryotic cells do not contain DNA gyrase or topoisomerase IV.
- However, when Topoisomerase IV alone was inhibited, decatenation was almost completely blocked.
- Cadmium has been shown to be carcinogenic due to interactions with DNA topoisomerase II?.
- It works by blocking the topoisomerase enzyme that is essential for cancer cells to proliferate.
- Gyrase ( a form of topoisomerase ) relaxes and undoes the supercoiling caused by helicase.
- Topoisomerase 1 inhibition is synthetically lethal with deficiency of expression of certain DNA repair genes.
- In cancers, the topoisomerase II-alpha is highly expressed in highly proliferating cells.
- Both gyrase and topoisomerase IV CTDs bend DNA, but only gyrase introduces negative supercoils.
- It also shows an antileishmanial activity in animal models being an inhibitor of topoisomerase I.
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