Other compounds they discovered include colchicine and veratrine.
2.
As is the case for antiepileptic drugs that act on voltage-dependent sodium channels, lamotrigine inhibited the release of glutamate and aspartate evoked by the sodium-channel activator veratrine and was less effective in the inhibition of acetylcholine or GABA release.
3.
The great advantage of purified morphine was that a patient could be treated with a known dose whereas with raw plant material, as Gabriel Fallopius once lamented, " if soporifics are weak they do not help; if they are strong they are exceedingly dangerous . " Morphine was the first pharmaceutical isolated from a natural product, and this success encouraged the isolation of other alkaloids : by 1820, isolations of noscapine, strychnine, veratrine, colchicine, caffeine, and quinine were reported.
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